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KMID : 1123920170310060328
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 6 p.328 ~ p.333
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Extracts of Desmodii Herba Suppresses of Rheumatoid Arthritis
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Noh Eun-Mi
Song Hyung-Kyung
Kim Jeong-Mi
Lee Guem-San
Kwon Kang-Beom
Lee Young-Rae
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Abstract
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Desomodii Herba (DH) has been shown to exhibit pharmacologyical activities, such as increase myocaridal contraction and secretion of hepatic bile. DH is used to reduce pain caused by rheumatoid arthritis(RA) in Korean medicine. However, the DH exact(DHE) effect and mechanism on rheumatoid arthritis are unknown. In this study, we aimed at the inhibitory effect of DHE on rheumatoid arthritis, and investigated the effect in collagen-induced mice arthritis model and TNF-αinduced MMP-1 and MMP-3 expression including the molecular basis in rheumatoid arthritis synovial fibroblasts (RASFs).The effect of DHE on RA was measured by clinical scoring system. In RASFs, expression of MMP-1 and MMP-3 was assessed by Western blotting and real-time PCR. Also, Western blotting used to evaluate the phosphorylation levels of p38, ERK and JNK and activation of NF-κB and AP-1. Our results showed that DHE reduced collagen-induced arthritis in mice. DHE inhibits TNF-αinduced MMP-1 and MMP-3 expression and mRNA levels in RASFs. The inhibitory effect of DHE was mediated by the inhibition of the AP-1/JNK signaling pathway. Taken together, our results suggest that the DHE may have preventive potential for rheumatoid arthritis.
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KEYWORD
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Desomodii Herba(廣金錢草), Rheumatoid arthritis, MMPs, AP-1
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